Spray a 9 x 13 baking dish. Preheat oven to 350 degrees.
In a large pot of salted water cook pasta per directions on back of package for al dente. Drain pasta and place back in pot.
Place chicken into a large mixing bowl. Add in thawed, drained, & chopped spinach.
Add in cream of soup, milk, chicken broth, garlic powder, onion powder, salt, & pepper. Mix well to combine.
Add in 4 oz shredded cheese, cooked & drained pasta, 1/2 of the French's fried onions. Mix well to combine.
Pour mixture into prepared baking dish. Spread evenly. Top with remaining shredded cheese & the rest of French's fried onions.
Bake in preheated oven for 1 hour until heated through and cheese has melted.