In a large bowl mix together ground beef, onion, eggs, milk, panko crumbs, garlic powder, paprika, salt, and black pepper. Place 1/2 of the meatloaf mixture into bottom of prepared loaf pan. Smooth evenly. Using a spoon make a gully in the bottom portion of meatloaf.
In the bottom portion of meatloaf mixture in loaf pan place sliced cream cheese in the gully shape from one end to the other end of gully.
Place 2/3 of the sliced blanched jalapenos on top of the cream cheese slices. Sprinkle cheddar cheese on top of jalapenos.
Place remaining meatloaf mixture on top of the fillings and smooth out evenly making sure to seal the top of the meatloaf mixture to the bottom meatloaf mixture to keep cheese from oozing out.
Top with ketchup. Lay bacon across top to cover ketchup. Top with extra jalapeno slices.
Bake in preheated oven for 60-70 minutes until meatloaf is cooked through and bacon is crisp.
Allow to rest for 10 minutes before removing from pan. Once removed from pan, rest for 5 minutes before serving.